The objective of the present work was to develop a self-emulsifying drug delivery system (SEDDS) for poorly water-soluble drug – leflunomide, to enhance its dissolution which could improve its oral absorption. The liquid SEDDS consisted of capmul MCM 8 as a vehicle for leflunomide, acrysol K 140 as a surfactant and transcutol P as a co-surfactant. Characterization of the SEDDS was performed by droplet size analysis, zeta potential and turbidity measurement. Ternary phase diagram was constructed to identify the self-emulsifying region after evaluation of leflunomide SEDDS by the visual observation. In-vitro dissolution test carried out for formulated leflunomide SEDDS filled in gelatine capsules. The present study revealed that the SEDDS can increase leflunomide dissolution rate and has the potential to enhance its oral bioavailability.
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